OpenTox:Current events

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eNanoMapper in nano compendium

For several years now, the research community has responded by launching very valuable projects under the Sixth Framework Programme FP6 and Seventh Framework Programme FP7, marking significant technological progress both in the technology and in its safety management.

About fifty projects are either completed or running and represent a total RTD investment of €137M, from the NMP and other programmes, under FP6 (13 projects, €31M) and FP7 (34 projects, €106M).

These projects together with a significant number of projects supported by government resources in the EU member states and the FP7 associated states, and other projects addressing safety as side objective,represent the valuable efforts of the scientific and industrial research community for progress.

Please, click on this link to view the recently published European NanoSafety Cluster Compendium, which contains information on all running or recently completed projects funded under the Seventh Framework Programme FP7.

You can find eNanoMapper project on the side 9.

OpenTox 2014

OpenTox 2014 (Get more information here): The OpenTox Euro series of meetings emerged as a continuation of the EU-funded Health-FP7 project OpenTox which was completed successfully in August 2011. Our ambitious plan is to develop OpenTox further as an infrastructure and community with annual events held in Europe and the USA in the area of predictive toxicology and related fields.

The OpenTox meetings are aiming at discussing the latest developments in predictive toxicology, including in silico modelling and application development, integrated data analysis, systems biology, visualisation, cheminformatics and bioinformatics.

Hands-on workshops on developments and applications enable participants to try out methods and software applied to predictive toxicology problems.

eCheminfo Workshop

The Scientists Against Malaria (SAM) initiative was formed with the goal of designing novel drug candidates against malaria (http://www.scientistsagainstmalaria.net/). During its first phase participants progressed target selection and modelling, computational screening, biological materials and assay preparation, through to the completion of initial experimental testing in the laboratory. The project has been initially focused on parastic kinases as novel targets for the potential development of a new class of anti-malaria drugs.

SAM is now being expanded as case study work supported by the eCheminfo community of practice which brings practitioners together with interests in the development and application of drug design methods. eCheminfo workshops provide an opportunity for scientists to participate in the modelling and design of libraries of molecules as potential lead candidates.

The next eCheminfo community of practice activity will involve a hands-on drug discovery workshop taking place in Oxford the week of 21-25 July. This workshop activity was initiated in 2006 to provide a setting where participants could learn and apply computational methods to drug design.

As in previous workshops the emphasis is on problem solving, practical hands-on use of methods and software, and working together throughout the week. In addition to the faculty-guided learning and exercises, this year's workshop will also offer a neglected disease case study focused on the discovery of new inhibitors of malarial kinases. Different methods will be applied to malarial proteins throughout the week to build and refine protein structures, carry out virtual screening, examine protein-drug interactions, form consensus models and include molecular properties such as potential toxic liabilities in the decision making framework.

More information on the program is available at http://www.douglasconnect.com/events/echeminfo-2014.

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